| Name | Address | Floor(s) | FEMA ID | Phone | Fax | E-mail | Website |
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| Candlewood Suites (cgicw) | 485 South Mt Auburn Rd
Cape Girardeau, Missouri 63703 | 4 | MO5225 | (573) 334-6868 | (573) 334-6869 |
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| Drury Lodge | 104 S Vantage
Cape Girardeau, Missouri 63702 | 1 | MO0368 | (573) 334-7151 | (573) 334-7151 | | |
| Drury Plaza Hotel Cape Conference Center | 3351 Percy Dr
Cape girardeau, Missouri 63701 | 8 | MO5414 | (800) 436-3310 | |
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| Drury Suites Cape Girardeau | 3303 Campster Dr
Cape Girardeau, Missouri 63701 | 5 | MO0386 | (573) 339-9500 | |
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| Hampton Inn Cape Girardeau I-55 East | 207 South Mt Auburn Rd
Cape girardeau, Missouri 63703 | 4 | MO5371 | (573) 334-4499 | (573) 334-5100 |
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| Holiday Inn Express Hotel & Suites | 3253 William St
Cape Girardeau, Missouri 63701 | 4 | MO5084 | (573) 334-4491 | (573) 334-4261 |
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| Holiday Inn West Park | 3257 William St
Cape Girardeau, Missouri 63701 | 2 | MO0432 | (573) 334-4491 | (573) 334-7459 | | |
| Super 8 Cape Girardeau | 2011 N Kingshighway
Cape Girardeau, Missouri 63701 | 2 | MO5144 | (573) 339-0808 | (573) 339-2060 |
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