Indiana's Commission on Interstate Cooperation promotes cooperation with other states and with the federal government. It acts largely through the Council of State Governments. Indiana is a member of such interstate regulatory bodies as the Great Lakes Commission, the Interstate Mining Compact Commission, the Midwest Interstate Low-Level Radioactive Waste Compact Commission, the Ohio River Basin Commission, and the Ohio River Valley Water Sanitation Commission.
The Indiana-Kentucky Boundary Compact was signed by Indiana in 1943 and received congressional approval the same year. In 1985, Indiana joined seven other states in signing a Great Lakes Charter, aimed at further protecting the lakes' resources. Federal grants to Indiana totaled over $5.8 billion in fiscal year 2001.