The Pierre Regional Airport, located three miles from central Pierre, includes offices, and boarding and baggage terminals. It is served by Mesaba (a Northwest Airlink) and Great Lakes Aviation. Greyhound and Jack Rabbit offer bus transportation.
U.S. highway 148 runs north and south through Pierre, connecting State Highway 34 that runs east and west and U.S. Highway 14/83 that extends eastward to Pierre from Ft. Pierre and turns north, then northeast as it runs through the city of Pierre. Other main streets are Missouri, Dakota, and Sioux avenues, which run east and west, and Capitol, Nicolett, and Broadway avenues, which surround the State Capitol Building.