U.S. Highway 14 and State Highway 30 run east and west through Rochester, while U.S. Highway 52 and U.S. Highway 63 run north and south. Interstate 35 is 35 miles west of the city. Rochester International Airport, located south of the city just off U.S. Highway 63, handled 277,504 passengers in 2004. The airport is served by American Airlines, which has daily flights to Chicago, and Northwest Airlines, with daily flights to Minneapolis. Local van service is also available to Minneapolis Airport. Plans for expansion are currently underway to increase its capacity by extending the primary runway. Intercity bus lines include Greyhound and Rochester. Daily bus service is offered to Winona, Minnesota, 45 miles east, where the closest Amtrak depot is located.
In Rochester, streets generally run east and west, and avenues run north and south. The city is divided into quadrants designated NW, NE, SW and SE. Broadway is the east/west divider street, and Center Street is the north/south divider street. Local bus service is provided by Rochester City Lines.