The pair will throw down as the co-main event on the stacked card headlined by Crawford’s fight with WBA super welterweight champion Israil Madrimov.
The winner of the Tszyu-Ortiz fight would then likely be able to challenge the winner of Crawford’s following fight with Fundora later this year.
Tszyu has been medically suspended from fighting in Las Vegas until May 15 following his bloody war with Fundora last month where the new champ also suffered a broken nose.
Tszyu’s brave decision to turn his attention to Ortiz — an undefeated fighter — has been widely praised, but has also been described as dangerous.
It has been an extraordinary series of unfortunate events for Tszyu, who could easily have retained his title against Fundora if not for the accidental elbow that opened up a deep cut at the top of his forehead in Round 2.
Had Tszyu’s camp stopped the fight before the fourth round, the Sydneysider could have walked away with a “no-contest” ruling.
Ortiz, a former welterweight world champ, has moved to the superwelterweight division after crushing every opponent put in front of him in the lower weight class.
Ortiz improved his undefeated record to a perfect 21-0 with all 21 wins coming via knockout when he sent Dulorme crashing to the floor in their Los Angeles fight.
It took Ortiz just two minutes before dropping his opponent with a savage kidney shot.